89-73-6水杨羟肟酸,99%

CAS号： 89-73-6

分子式： C7H7NO3 分子量： 153.14

• 水杨基羟肟酸

  英文名：salicylhydroxamic acid

  CAS：	89-73-6	精确质量：	153.04300
  分子式：	C7H7NO3	LogP：	0.90210
  分子量：	153.13500	PSA：	69.56000

89-73-6水杨羟肟酸,99%化合物描述

Salicylhydroxamic acid (SHA or SHAM) is a drug that is a potent and irreversible inhibitor of bacterial and plant urease usually used for urinary tract infections. The molecule is similar to urea but is not hydrolyzable by the urease enzyme. It is also a trypanocidal agent. When administered orally, it is metabolized to salicylamide which exerts analgesic, antipyretic and antiinflammatory effects.
Salicylhydroxamic acid is also a common ligand utilized in the synthesis of metallacrowns.
In plants, some fungi and some protists with the alternative oxidase (AOX) enzyme in the mitochondrial electron transport chain system, salicylhdroxamic acid acts as an inhibitor of the enzyme, blocking the largely uninhibited flow of electrons through AOX. AOX acts as a "short circuit" of the normal electron chain, dissipating electrons with a much-decreased translocation of protons, and therefore diminished production of ATP by oxidative phosphorylation. When AOX is blocked by SHAM, electrons are forced through the cytochrome pathway and through cytochrome IV, allowing observation of the operation of the cytochrome pathway without AOX activity. The AOX pathway is found to be the exclusive electron transport pathway in Trypanosoma brucei, the organism that causes African Sleeping Sickness, meaning that SHAM completely shuts down oxygen consumption by this organism.

89-73-6水杨羟肟酸,99%基本信息

• 中文名称：

  水杨基羟肟酸

• 中文别名：

  邻羟基苯甲酰异羟肟酸;
  N-羟基邻羟基苯甲酰胺;
  水杨羟肟酸;
  N,2-二羟基苯甲酰胺;
  水杨酰胺肟;
  

• 英文名称：

  salicylhydroxamic acid

• 英文别名：

  N,2-dihydroxybenzamide;
  Benzamide, N,2-dihydroxy-;
  

• CAS号：

  89-73-6

• 分子式：

  C7H7NO3

• 分子量：

  153.13500

• 精确质量：

  153.04300

• PSA：

  69.56000

• LogP：

  0.90210

物化性质

• 外观与性状：

  褐色结晶粉末

• 密度：

  1.402g/cm3

• 熔点：

  177 °C (dec.)(lit.)

• 闪点：

  248.9oC

• 折射率：

  1.626

• 稳定性：

  Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.

• 储存条件：

  Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

安全信息

• 安全说明：

  S22-S26-S36-S24/25

• 海关编码：

  2924299090

• 危险品标志：

  Xn

• 危险类别码：

  R40

• RTECS号：

  VO6870000

• WGK Germany：

  3

生产方法及用途

• 用途

  有机试剂。分析铋、铜、镍和铅,也可沉淀银、镉、钴、铁、汞、镁、锰和钒等。