130-85-8帕莫酸,98%

CAS号： 130-85-8

分子式： C23H16O6 分子量： 388.38

• 帕莫酸

  英文名：pamoic acid

  CAS：	130-85-8	精确质量：	388.09500
  分子式：	C23H16O6	LogP：	4.39140
  分子量：	388.37000	PSA：	115.06000

130-85-8帕莫酸,98%化合物描述

Pamoic acid, also called embonic acid, is a naphthoic acid derivative. Salts and esters of pamoic acid are known as pamoates or embonates. It can be prepared by the reaction of 2-hydroxy-3-naphthoic acid with formaldehyde.
In pharmacology, the salt form of pamoic acid (pamoate ion) can be used as a counter ion of a drug compound to increase the solubility of the drug in water. The presence of multiple oxygen atoms enables significant hydrogen bonding to occur. Hydrogen bonds facilitate the dissolution of compounds in water.
Pamoic acid has agonist activity for the orphan G protein-coupled receptor GPR35 by which it activates ERK and beta-arrestin2, and causes antinociceptive activity. Although (like other drug salts) it has been considered an inactive compound by the FDA, these recent data suggest that its permitted uses may need to be reexamined.

130-85-8帕莫酸,98%基本信息

• 中文名称：

  帕莫酸

• 中文别名：

  哌酸;
  亚甲基双羟萘酸;
  4,4'-亚甲基二(3-羟基-2-萘甲酸);
  扑酸;
  2,2'-二羟基-1,1'-二萘甲烷-3,3'-二羧酸;
  

• 英文名称：

  pamoic acid

• 英文别名：

  Pamoic;
  Pamoic Acid;
  1,1'-Methylene-bis(2-hydroxy-3-naphthoic acid);
  2-Naphthalenecarboxylic acid, 4,4‘-methylenebis[3-hydroxy-;
  4,4-Methylenebis(3-Hydroxy-2-Naphthoic Acid);
  EMBIONIC ACID;
  PAMOIC ACID FREE ACID;
  Pamoic acid;
  PAMOIC ACID pure;
  Embonic acid;
  4,4'-Methylenebis(3-hydroxy-2-naphthoic Acid);
  

• CAS号：

  130-85-8

• 分子式：

  C23H16O6

• 分子量：

  388.37000

• 精确质量：

  388.09500

• PSA：

  115.06000

• LogP：

  4.39140

物化性质

• 外观与性状：

  细黄色粉末

• 密度：

  1.499 g/cm3

• 熔点：

  ≥300 °C (dec.)

• 沸点：

  642.7oC at 760 mmHg

• 闪点：

  356.5oC

• 水溶解性：

  PRACTICALLY INSOLUBLE

• 储存条件：

  Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

• 蒸汽压：

  2.13E-17mmHg at 25°C

安全信息

• 安全说明：

  S26-S36

• 海关编码：

  2917399090

• 危险品标志：

  Xi

• 危险类别码：

  R36/37/38

• RTECS号：

  QL2180000

• WGK Germany：

  3

生产方法及用途

• 生产方法

  生产方法简介 由2-羟基-3-萘酸与甲醛缩合而制得

• 用途

  用途 其盐用于抗疟、驱虫等,疗效佳,有长效作用。