70-70-24''-羟基苯丙酮,98%

CAS号： 70-70-2

分子式： C9H10O2 分子量： 150.18

• 对羟基苯丙酮

  英文名：4'-Hydroxypropiophenone

  CAS：	70-70-2	精确质量：	150.06800
  分子式：	C9H10O2	LogP：	1.98490
  分子量：	150.17400	PSA：	37.30000

70-70-24''-羟基苯丙酮,98%化合物描述

Paroxypropione (INN) (brand names Frenantol, Frenormon, Hypophenon, Paroxon, Possipione, Profenone, numerous others; former developmental code name NSC-2834), also known as paroxypropiophenone (P.O.P.) or 4'-hydroxypropiophenone, is a synthetic, non-steroidal estrogen that has been used medically as an antigonadotropin in Spain and Italy.
Paroxypropione is closely related structurally to p-hydroxybenzoic acid and parabens such as methylparaben, and also bears a close resemblance to diethylstilbestrol (which, in fact, produces paroxypropione as an active metabolite) and alkylphenols like nonylphenol, all of which are also estrogens. The drug possesses relatively low affinity for the estrogen receptor and must be given at high dosages to achieve significant estrogenic and antigonadotropic action, for instance, 0.8 to 1.6 g/day. Paroxypropione was first synthesized in 1902. Its antigonadotropic properties were discovered in 1951 and it entered clinical use shortly thereafter.; Similarly to p-hydroxybenzoic acid, paroxypropione has been found to possess antioxidant activity.
Paroxypropione is a precursor in the chemical synthesis of diethylstilbestrol and dienestrol.

70-70-24''-羟基苯丙酮,98%基本信息

• 中文名称：

  对羟基苯丙酮

• 中文别名：

  4-羟基苯丙酮;
  4'-羟基苯丙酮;
  对羟苯丙酮;
  

• 英文名称：

  4'-Hydroxypropiophenone

• 英文别名：

  Paroxypropione;
  4'-hydroxy-propiophenone;
  H-365;
  1-Propanone, 1-(4-hydroxyphenyl)-;
  Mepal;
  para-hydroxy-propiophenone;
  Hypostat;
  p-HOC6H4COEt;
  p-hydroxypropiophenone;
  PHP;
  Paroxon;
  Bio-Fren;
  Frenon;
  B 360;
  

• CAS号：

  70-70-2

• 分子式：

  C9H10O2

• 分子量：

  150.17400

• 精确质量：

  150.06800

• PSA：

  37.30000

• LogP：

  1.98490

物化性质

• 外观与性状：

  白色晶体

• 密度：

  1.104 g/cm3

• 熔点：

  36-38 °C(lit.)

• 沸点：

  152-154 °C26 mm Hg(lit.)

• 闪点：

  >230 °F

• 折射率：

  1.542

• 水溶解性：

  0.34 g/l (15 oC)

安全信息

• 安全说明：

  S37-S24/25-S36-S26

• 海关编码：

  29145000

• 危险品标志：

  Xn; Xi

• 危险类别码：

  R36/37/38

• RTECS号：

  UH1925000

• WGK Germany：

  3

生产方法及用途

• 生产方法

  将无水三氯化铝加入二硫化碳中，搅拌，滴加丙酸苯酯，反应立即发生并放出氯化氢，因反应放热而使二硫化碳回流。滴加完毕，将反应混合物加热回流2h，至氯化氢不再逸出。蒸除二硫化碳，升温至140-150℃保温3h，又放出氯化氢。将生成的树脂状物质冷却，缓缓加入盐酸和水，使铝的复盐分解。放置冰箱中过夜，过滤，将滤饼用甲醇重结晶，得对羟基苯丙酮，收率34-39%。

• 用途

  用作液晶原料及中间体。