3687-18-13-氨基丙烷磺酸,97%

CAS号： 3687-18-1

分子式： C3H9NO3S 分子量： 139.17

• 3-氨基-1-丙磺酸

  英文名：3-Amino-1-propanesulfonic acid

  CAS：	3687-18-1	精确质量：	139.03000
  分子式：	C3H9NO3S	LogP：	1.00410
  分子量：	139.17300	PSA：	88.77000

3687-18-13-氨基丙烷磺酸,97%化合物描述

Homotaurine (3-amino-1-propanesulfonic acid (3-APS) or tramiprosate (INN)) is a synthetic organic compound. It is analogous to taurine, but with an extra carbon in its chain. It has GABAergic activity, apparently by mimicking GABA, which is it resembles.
Homotaurine was investigated in a Phase III clinical trial as a potential treatment for Alzheimer's disease that did not show efficacy in its primary endpoints. In preclinical studies it had been found to bind to soluble amyloid beta and inhibit the formation of neurotoxic aggregates. Homotaurine has also shown anticonvulsant activities, reduction in skeletal muscle tonus, and hypothermic activity.
Homotaurine has been reported as a GABA antagonist as well as a GABA agonist. In vitro studies have found that homotaurine is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy, becoming an antagonist and a displacing full agonist of GABA or baclofen at this receptor. In a study in rats, homotaurine reversed the catatonia induced by baclofen (the prototypical GABAB agonist), and was able to produce analgesia via the GABAB receptor, an effect that was abolished when CGP 35348, a GABAB receptor antagonist was applied.
One study in rats showed that homotaurine suppressed ethanol-stimulated dopamine release, as well as ethanol intake and preference in rats in a way similar to acamprosate. Acamprosate, the N-acetyl derivative of homotaurine, was approved by the FDA in 2004 to treat alcohol dependence.

3687-18-13-氨基丙烷磺酸,97%基本信息

• 中文名称：

  3-氨基-1-丙磺酸

• 中文别名：

  3-氨基-1-丙烷磺酸;
  高牛磺酸;
  3-氨基丙烷磺酸;
  

• 英文名称：

  3-Amino-1-propanesulfonic acid

• 英文别名：

  3-aminopropane-1-sulfonic acid;
  Tramiprosate;
  Homotaurine;
  3-Amino-1-propanesulfonic acid;
  

• CAS号：

  3687-18-1

• 分子式：

  C3H9NO3S

• 分子量：

  139.17300

• 精确质量：

  139.03000

• PSA：

  88.77000

• LogP：

  1.00410

物化性质

• 外观与性状：

  白色晶体或结晶粉末

• 密度：

  1.387 g/cm3

• 熔点：

  293 °C (dec.)(lit.)

• 储存条件：

  Store at 0-5°C

安全信息

• 危险类别码：

  R36/37/38

• 危险品标志：

  Xi

• WGK Germany：

  1

• 安全说明：

  S26-S36

• 海关编码：

  2921199090

生产方法及用途

• 用途

  用作酒精中毒治疗剂阿坎酸的中间体。